In a small bowl, mix together the hickory liquid smoke, garlic salt, onion salt, and Worcestershire sauce.
Pour the marinade mixture over the brisket, ensuring it is evenly coated.
Add a little water to the bottom of the dish.
Cover the dish and refrigerate overnight to allow the flavors to meld.
The next day, bake the brisket in the preheated oven for 6 hours, or until it is tender and easily shreds with a fork.
Once done, remove from the oven and let it rest for a few minutes before slicing.
Serve hot, and enjoy the smoky, tender goodness.
Notes / Tips / Wine Advice:
Wine Advice:Pair this rich and smoky beef brisket with a bold red wine such as Malbec. Its deep flavors and smooth texture will complement the hearty nature of the dish, creating a perfect balance on the palate.